Survival of AML patients receiving HLA-matched sibling donor allogeneic bone marrow transplantation correlates with HLA-Cw ligand groups for killer immunoglobulin-like receptors
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چکیده
منابع مشابه
HLA-matched sibling bone marrow transplantation for β-thalassemia major.
We describe outcomes after human leukocyte antigen-matched sibling bone marrow transplantation (BMT) for 179 patients with β-thalassemia major. The median age at transplantation was 7 years and the median follow-up was 6 years. The distribution of Pesaro risk class I, II, and III categories was 2%, 42%, and 36%, respectively. The day 30 cumulative incidence of neutrophil recovery and day 100 pl...
متن کاملبهبود بقا بیماران مبتلا به لوسمی لنفوبلاستیک حاد فاقد HLA-A3/11 برای KIR3DL2 دهنده پس از پیوند سلول های بنیادی خونساز از خواهر یا برادر با HLA مشابه بدون تخلیه سلول T
A potential factor influencing hematopoietic stem cells transplantation (HSCT) outcome is the presence of donor-derived alloreactive natural killer (NK) cells. This retrospective analysis studied the impact of NK alloreactivity based on the missing KIR ligand, for acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL) patients undergoing non-T-cell depleted HLA-identical sibling HS...
متن کاملAllogeneic Bone Marrow Transplantation in Leukemic HLA-Matched Patients: A Cytogenetic Documentation
We evaluated serially by cytogenetics the blood and marrow chimerism of 38 leukemic recipients of HLA-matched bone marrow transplants (BMT) who were prepared by high doses of alkylating agents and fractionated total-body irradiation (2.2 Gy x 5). Donor or host mitoses were identifled by examination of sex chromosomes in 32 patients or by evaluation of the polymorphism of other chromosomes after...
متن کاملImproved outcome in HLA-identical sibling hematopoietic stem-cell transplantation for acute myelogenous leukemia predicted by KIR and HLA genotypes.
Inhibitory killer immunoglobulin (Ig)-like receptors (KIRs) recognize HLA-C and -B epitopes on target cells, thereby regulating natural killer (NK) cell activity. In 178 patients receiving T-cell-depleted HLA-identical sibling transplants for acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML), acute lymphoblastic leukemia (ALL), or myelodysplastic syndrome (MDS), analysis of d...
متن کاملBone marrow transplantation in leukemia in the absence of an HLA-identical sibling donor.
Bone marrow transplantation is a potentially curative treatment for patients with leukemia, aplastic anemia, metabolic disorders, and immunodeficiency. One of the main problems ofthis procedure is the graftversus-host reaction induced in the recipient by the immune function of the transplanted marrow. In order to minimize the risks of graft rejection and graft-versus-host disease (GVHD), marrow...
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ژورنال
عنوان ژورنال: Bone Marrow Transplantation
سال: 2007
ISSN: 0268-3369,1476-5365
DOI: 10.1038/sj.bmt.1705609